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A study A study conducted in Wales found increased mortality in women with Staphylococcus aureus Bacteremia (SAH), with sepsis-related mortality identified as an underlying cause of the disparity, researchers reported yesterday in JAMA network opened.

Using a database of anonymized, population-wide electronic health records, researchers at Cardiff University examined data from all adults diagnosed with SAH between April 2010 and March 2022. They compared 30- and 90-day all-cause mortality in men and women using SAH using logistic regression adjusted for covariates including age, hospital- or community-related SAH, methicillin resistance, and Charlson comorbidity index score.

The 7,515 adults with SAH identified for the study included 4,755 (63%) male patients and 2,760 (37%) female patients. Overall mortality 30 days after SAH was 2,057 deaths (27%), including 1,262 in men (27%) and 795 in women (29%). The overall mortality 90 days after SAH was 2,712 (36%), of which 1,690 (36%) were in men and 1,022 (37%) in women.

Further research into the underlying factors is needed

In adjusted models, female gender was associated with both 30-day values ​​(odds ratio). [OR]1.19; 95% confidence interval [CI]1.06 to 1.34) and 90-day mortality (OR 1.15; 95% CI 1.03 to 1.29). However, using an adjusted competing risks regression model for 30-day mortality, female gender was associated with SAH deaths due to sepsis (hazard ratio, 1.21; 95% CI, 1.02 to 1.44). not with other causes (hazard ratio 1.10; 95%). CI, 0.99 to 1.23).

The study authors say the results confirm the findings of a systematic review and meta-analysis published in the same journal in February.

“Further research is needed to investigate the underlying pathophysiological, social, and health-related factors underlying sex-related mortality differences in SAH,” they wrote. “Eliminating these disparities could lead to more targeted therapies, improved survival rates and more equitable health outcomes for both genders.”