Ohio State vs. Penn State Prediction, Odds, Spread: 2024 college football tips, prop bets from top experts

The No. 4 Ohio State Buckeyes (6-1, 3-1) head out to solidify their College Football Playoff career by traveling to Happy Valley to face the No. 3 Penn State Nittany Lions (7-0, 4-0) at Beaver Stadium on Saturday. The Buckeyes bounced back from their first loss of the season to beat Nebraska 21-17 last week. Penn State was dominant in 2024, winning the majority of its games in overwhelming fashion. In their last game, the Nittany Lions beat Wisconsin on the road 28-13. Both teams are 3-4 in the standings, and Ohio State leads the all-time series at 24-14. Penn State quarterback Drew Allar (leg) does not carry a questionable or out label on the availability report, meaning he is expected to play.

Kickoff in Happy Valley is scheduled for noon ET. The Buckeyes have a 3-point advantage in the latest Penn State vs. Ohio State odds, according to the SportsLine consensus, while the over/under is at 47.5 points. Before making your Ohio State vs. Penn State picks, check out the Week 10 college football predictions and betting tips from SportsLine's Jimmie Kaylor.

Kaylor is an NFL, college football and DFS expert for SportsLine and has been covering the NFL and college football for nearly a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and determining his betting tips. He has his finger on the pulse of the college football landscape and has made big profits on sports betting apps over the past two years.

Kaylor has destroyed college football sportsbooks over the past two seasons, posting a whopping 71.1 units and posting a 191-112-3 record since Week 1 of the 2023 season. All of his picks have been featured on his SportsLine expert page or in his weekly byline articles. Anyone who has followed his tips will be at the top.

Now, Kaylor tuned in to the Ohio State vs. Penn State game on Saturday and just revealed his college football picks and predictions. You can head over to SportsLine now to see his picks. Here are the college football odds and college football betting lines for Penn State vs. Ohio State:

• Ohio State vs. Penn State distribution: Ohio State -3
• Ohio State vs. Penn State over/under: 47.5 points
• Money line Ohio State vs. Penn State: Ohio State -159, Penn State +132
• Ohio State vs. Penn State picks: See picks at SportsLine
• Ohio State vs. Penn State Streaming: FuboTV (Try Free)

Why Ohio State can cover

As has become the norm, Ohio State is once again loaded with top-tier talent and future NFL draft picks. On the defensive side of the ball, the Buckeyes are led by defensive tackle Tyleik Williams and safety Caleb Downs. Williams has a tremendous interior presence but still leads the team with 2.5 sacks. Downs, a transfer from Alabama, is an All-America candidate and could be the best safety in college football.

Offensively, the Buckeyes are occupied at the wide receiver position. Freshman Jeremiah Smith leads the team with 623 yards and eight touchdowns. Senior Emeka Egbuka leads the team in receptions (43) with 546 yards and six touchdowns. The duo will continue to put pressure on Penn State's secondary. See which team you should choose here.

Why Penn State can cover

Penn State has been one of the most dominant teams in the country this season. Five of the Nittany Lions' seven wins have come by double figures, and they rank near the top of the Big Ten in both offense and defense. Penn State enters this matchup ranked fourth in the conference in points scored per game (33.3) and second in points per game allowed (14.3).

Penn State has a ton of offensive weapons that should help them keep pace with the Buckeyes, regardless of Allar's status. Tight end Tyler Warren leads the team with 47 catches for 559 yards and four touchdowns. Running backs Kaytron Allen (509 yards, four touchdowns) and Nicholas Singleton (483 yards, three touchdowns) give the Nittany Lions a strong one-two punch out of the backfield. See which team you should choose here.

Here's how to choose between Penn State and Ohio State

Kaylor analyzed the Ohio State vs. Penn State game from all angles and is going by the total score. He has also discovered a critical X-factor that causes him to jump over one side of the range. At SportsLine, he just shares what it is and which side he supports.

So who will win against Ohio State at Happy Valley Penn State on Saturday and what crucial X-factor makes one side of the spread a must-win? Visit SportsLine now to see which side of the spread you should jump on, all from the expert who has won $7,110 on $100 college football bettors since Week 1 of the 2023 season, and find out .