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BOSTON — Massachusetts voters have rejected a proposal to legalize natural psychedelic drugs, a setback for the growing legalization movement, according to a call from The Associated Press.

The measure would have allowed people 21 and older to consume psychedelics like psilocybin mushrooms at licensed treatment centers and grow small amounts at home.

The proposal followed successful campaigns to legalize and regulate psilocybin in Oregon and Colorado. The New Approach PAC, a national advocacy group, has poured millions of dollars into campaigns in all three states and will likely continue to push similar proposals across the country.

Opponents, including several major medical groups, argued that these drugs could be harmful, particularly to people at risk of schizophrenia or psychosis. They also feared the law would fuel a black market in homegrown psychedelics.

Advocates point to a growing body of research showing the potential of psychedelics to treat conditions such as depression and PTSD.