Jacksonville State vs. Liberty Prediction, Odds: College Football Picks 2024, Experts Betting on a 191-112 Run

The Liberty Flames (5-1, 3-1) will look to bounce back from a shocking upset loss when they host the Jacksonville State Gamecocks (4-3, 3-0) in a midweek Conference USA matchup on Wednesday. Liberty lost 27-24 to Kennesaw State in its last game, giving the Owls the program's first win against an FBS opponent. The loss ended the Flames' College Football Playoff hopes, but the conference title is still up for grabs. The Gamecocks have won four straight games, with each win being overwhelming. Jacksonville State defeated Middle Tennessee State 42-20 in its last game.

Kickoff in Lynchburg, Virginia is scheduled for 7:00 p.m. ET on CBS Sports Network. The Flames have a 2.5-point advantage in the latest Liberty-Jacksonville State odds, according to the SportsLine consensus, while the over/under is at 64 points, up half a point from the opener. Before you make any picks between Jacksonville State and Liberty, check out the Week 10 college football predictions and betting tips from SportsLine's Jimmie Kaylor.

Kaylor is an NFL, college football and DFS expert for SportsLine and has been covering the NFL and college football for nearly a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and determining his betting tips. He has his finger on the pulse of the college football landscape and has made big profits on sports betting apps over the past two years.

Kaylor has destroyed college football sportsbooks over the past two seasons, posting a whopping 71.1 units and posting a 191-112-3 record since Week 1 of the 2023 season. All of his picks have been featured on his SportsLine expert page or in his weekly byline articles. Anyone who has followed his tips will be at the top.

Now Kaylor tuned in to the Liberty vs. Jacksonville State game on Wednesday and just announced his college football picks and predictions. You can head over to SportsLine now to see his picks. Here are the college football odds and betting lines for Jax State vs. Liberty:

• Spread between Jacksonville State and Liberty: Liberty -2.5
• Jacksonville State vs. Liberty over/under: 64 points
• Moneyline Jacksonville State vs. Liberty: Liberty -134, Jacksonville State +113
• Jacksonville State vs. Liberty picks: See picks at SportsLine
• Jacksonville State vs. Liberty Streaming: FuboTV (Try Free)

Why Jacksonville State can cover

Jacksonville State has been on the rise over the last month, playing its best football of the season. The Gamecocks have won four straight games, averaging 34.8 points in each win. Jax State is also 4-0 against the spread during its winning streak.

The Gamecocks have the top-ranked offense in Conference USA. They enter the conference on Wednesday leading the conference with an average of 465.9 yards per game, 256.3 rushing yards per game and 39.7 points per game. Running back Tre Stewart leads the Gamecocks with 682 rushing yards and 11 rushing touchdowns. See which team you should choose here.

Why Liberty can cover

Like Jacksonville State, Liberty was dominant on offense in 2024, particularly running the ball. The Flames enter this matchup averaging 222.5 rushing yards and 31.8 points per game and are second only to Jax State in the C-USA rankings. Defensively, Liberty is also near the top of the conference in all major defensive categories.

Quarterback Kaidon Salter gives the Flames an advantage at the most important position on the field. The 6-foot-3 junior is widely considered a future NFL draft pick and could have a field day against Jacksonville State's defense. Salter enters this game with 1,280 passing yards, 10 touchdown passes and two interceptions and has rushed for 278 yards and two scores. See which team you should choose here.

How to pick Liberty vs. Jacksonville State

Kaylor analyzed Jax State vs. Liberty from all angles and is going by the total score. He has also discovered a critical X-factor that causes him to jump over one side of the range. At SportsLine, he just shares what it is and which side he supports.

So who wins Liberty vs. Jacksonville State on Wednesday and what key X-factor makes one side of the spread a must-win? Visit SportsLine now to see which side of the spread you should jump on, all from the expert who has won $7,110 on $100 college football bettors since Week 1 of the 2023 season, and find out .