Innovative bioelectronic device offers new hope in the fight against bacterial infections

In preclinical testing, the electroceutical patch demonstrated remarkable results, achieving a nearly tenfold reduction in bacterial colonization on pig skin. “Almost ten years ago, we discovered action potentials in bacterial biofilms and have since worked to show that bacteria not normally considered excitable are actually excitable and even perform functions similar to neurons in the brain,” said Süel, a professor at the UC San Diego School of Biological Sciences. “Our collaboration combined our biological insights with the incredible technical and scientific expertise of the Tian Group. “Together, we show that an important opportunistic pathogen is 'selectively excitable,' and the Tian group has developed a wearable device that can treat biofilm infections on the skin through electrotherapy without the need for antibiotics.”

This research represents a significant advance in bioelectronic medicine Researchers are optimistic that this device could soon be used in clinical settings, particularly for patients with chronic wounds or patients with medical implants. By harnessing the natural properties of bacteria, scientists can create more effective and personalized treatment options for people suffering from opportunistic infections.

Healthcare professionals are encouraged to explore the implications of this research for infection control and to stay abreast of future advances in bioelectronic therapies.

The research was funded by the Bill & Melinda Gates Foundation (INV-067331); the US Army Research Office (W911NF-24-1-0053); the National Science Foundation (MPS-2121044); the National Institutes of Health (R35GM13964); and US Army Research Office (W911NF-22-1-0107, W911NF-1-0361).

— By Brian Foley, Senior Communications Analyst, University of Chicago

Competing Interests Disclaimer: The University of Chicago and the University of California San Diego have filed provisional patent applications for the electrical stimulation devices. S. Kim, B. Tian and GMS are the inventors. All other authors declare no competing interests.