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49ers vs. Buccaneers: Live updates, score, top moments, analysis

The Niners are coming off a bye and the star running back Christian McCaffrey will make his season debut after sitting out the entire season with Achilles tendonitis and was released from injured reserve less than 24 hours ago.

On the other hand, the Bucs suffered a heavy overtime loss against the Kansas City Chiefs on Monday Night Football.

Follow us for highlights, Brady commentary and real-time analysis from FOX Sports NFL Reporter Henry McKenna.

Find the rest of Sunday's regular season action here Here.

11:22 p.m. ET

Live scoreboard

1:31 p.m. ET

Pearsall's first NFL TD after opening scoring for the 49ers

1:22 p.m. ET

Preview: Can the Niners bounce back after the bye?

Live coverage of this began at 11:27 p.m. ET